Evaluation of the Antidotal Effect of Promethazine on Dichlorvos Poisoning
Adetoye Omolayo Durojaiye, Udeme Owunari Georgewill

This study evaluated the antidotal effect of Promethazine on dichlorvos poisoning in wistar rats. A total of 65 adult rats were used. The animals were divided into 5 groups with 5 rats in group 1 and the remaining 4 groups were sub-divided into 3 groups each with 5 rats per group. Group A, received 15mg/kg dichlorvos only. Group B was post-treated with promethazine 0.375mg/kg, 0.75mg/kg and 1.5mg/kg five minutes after dichlorvos poisoning. Group C received promethazine 0.375mg/kg, 0.75mg/kg, 1.5mg/kg + atropine 1.6mg/kg respectively five (5) minutes after dichlorvos poisoning. Group D was post-treated with atropine alone 0.4mg/kg, 0.8mg/kg, and 1.6mg/kg five minutes after dichlorvos poisoning and Group E was pre-treated with promethazine alone 0.375mg/kg, 0.75mg/kg and 1.5mg/kg five minutes before dichlorvos poisoning. Results revealed that Promethazine hadantidotal effect in dichlorvos poisoning by increasing the onset of body tremor and onset of other reactions by more than 75%. A 100% survival rate was also recorded in animals that received Promethazine when compared with those exposed to dichlorvos only, especially at high dose . The combined administration of atropine and promethazine showed significant (p<0.05) antidotal activity as the latency to the onset of body tremors and other reactions were further delayed when compared to promethazine alone. Post-treatment model with Promethazine alone was comparable with the pre-treatment model but gave better outcome than pre-treatment model at low dose of 0.375mg/kg.This study therefore concludes that Promethazine alone or in combination with Atropine has potent antidotal effect in dichlorvos poisoning.

Full Text: PDF     DOI: 10.15640/ijmp.v6n2a7